Mus musculus
TLR4
Lps, Ly87, Ran/M1, Rasl2-8, RP24-209H15.1
toll-like receptor 4
GO Process (71)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- B cell proliferation involved in immune response [IMP]
- I-kappaB phosphorylation [IMP, ISO]
- activation of MAPK activity [IMP]
- activation of NF-kappaB-inducing kinase activity [NAS]
- activation of innate immune response [IMP]
- cellular response to lipopolysaccharide [IDA, IMP]
- cellular response to lipoteichoic acid [IMP]
- defense response to Gram-negative bacterium [IMP]
- detection of lipopolysaccharide [ISO, TAS]
- innate immune response [TAS]
- innate immune response-activating signal transduction [ISO]
- interferon-gamma production [IGI]
- intestinal epithelial structure maintenance [IMP]
- leukotriene metabolic process [ISO]
- lipopolysaccharide-mediated signaling pathway [IDA, IGI, ISO]
- macrophage activation [ISO, ISS]
- mast cell activation [NAS]
- microglial cell activation [ISO]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of interferon-gamma production [IMP]
- negative regulation of interleukin-17 production [IMP]
- negative regulation of interleukin-23 production [IMP]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of tumor necrosis factor production [IMP]
- nitric oxide production involved in inflammatory response [IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of DNA binding [ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA, IGI]
- positive regulation of MHC class II biosynthetic process [IMP]
- positive regulation of NF-kappaB import into nucleus [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of chemokine production [IDA, ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of interferon-alpha production [IDA]
- positive regulation of interferon-beta biosynthetic process [IMP]
- positive regulation of interferon-beta production [IDA]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-1 biosynthetic process [NAS]
- positive regulation of interleukin-1 production [IDA]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of interleukin-12 biosynthetic process [ISO]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-13 biosynthetic process [NAS]
- positive regulation of interleukin-6 biosynthetic process [NAS]
- positive regulation of interleukin-6 production [IDA, IMP, ISO, NAS]
- positive regulation of interleukin-8 biosynthetic process [ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of lymphocyte proliferation [IMP]
- positive regulation of macrophage cytokine production [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA]
- positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [IDA]
- positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of platelet activation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of stress-activated MAPK cascade [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor biosynthetic process [ISO]
- positive regulation of tumor necrosis factor production [IDA, IMP]
- regulation of inflammatory response [IMP]
- regulation of sensory perception of pain [ISO]
- response to bacterium [IMP]
- response to ethanol [ISO]
- response to fatty acid [ISO]
- response to lipopolysaccharide [IGI, IMP, ISO]
- response to oxidative stress [ISO]
- toll-like receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
204224
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- Interactors 28
- Interactions 36
- Network
- PTM Sites 1