Mus musculus
TNF
DIF, TNF-a, TNF-alpha, TNFSF2, TNFalpha, Tnfa, Tnfsf1a
tumor necrosis factor
GO Process (119)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- JNK cascade [IGI]
- MAPK cascade [ISO]
- activation of MAPK activity [ISO]
- activation of MAPKKK activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- apoptotic process [ISO]
- apoptotic signaling pathway [IDA]
- calcium-mediated signaling [ISO]
- cell activation [ISO]
- cell proliferation [TAS]
- cellular extravasation [IDA]
- cellular response to amino acid stimulus [IDA]
- cellular response to lipopolysaccharide [IDA]
- cellular response to nicotine [ISO]
- cellular response to organic cyclic compound [ISO]
- chronic inflammatory response to antigenic stimulus [ISO]
- defense response [IMP]
- defense response to Gram-positive bacterium [IGI]
- defense response to bacterium [IDA]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- epithelial cell proliferation involved in salivary gland morphogenesis [IDA]
- extracellular matrix organization [IDA]
- extrinsic apoptotic signaling pathway [IGI, ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [IGI, ISO]
- glucose metabolic process [IDA]
- humoral immune response [IMP]
- inflammatory response [IGI, ISO, TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- leukocyte migration [IDA]
- leukocyte tethering or rolling [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO]
- multicellular organismal development [IMP]
- necroptotic signaling pathway [IGI, ISO]
- negative regulation of L-glutamate transport [ISO]
- negative regulation of alkaline phosphatase activity [IDA]
- negative regulation of branching involved in lung morphogenesis [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cytokine secretion involved in immune response [ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of glucose import [IDA, ISO]
- negative regulation of growth of symbiont in host [IGI]
- negative regulation of interleukin-6 production [ISO]
- negative regulation of lipid catabolic process [ISO]
- negative regulation of myoblast differentiation [IMP]
- negative regulation of osteoblast differentiation [IDA]
- negative regulation of protein complex disassembly [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of viral genome replication [ISO]
- organ morphogenesis [IMP]
- osteoclast differentiation [IGI]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IGI, ISO]
- positive regulation of JNK cascade [IDA, IGI]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of NF-kappaB import into nucleus [IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of action potential [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of calcidiol 1-monooxygenase activity [ISO]
- positive regulation of cell proliferation [TAS]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [ISO]
- positive regulation of chemokine biosynthetic process [ISO]
- positive regulation of chemokine production [ISO]
- positive regulation of chronic inflammatory response to antigenic stimulus [IGI]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of cytokine production [ISO]
- positive regulation of cytokine secretion [ISO]
- positive regulation of fever generation [IDA]
- positive regulation of gene expression [ISO]
- positive regulation of hair follicle development [IMP]
- positive regulation of heterotypic cell-cell adhesion [ISO]
- positive regulation of humoral immune response mediated by circulating immunoglobulin [IGI]
- positive regulation of inflammatory response [ISO]
- positive regulation of interferon-gamma production [IGI]
- positive regulation of interleukin-18 production [ISO]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of interleukin-8 biosynthetic process [ISO]
- positive regulation of membrane protein ectodomain proteolysis [ISO]
- positive regulation of mitosis [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of podosome assembly [ISO]
- positive regulation of programmed cell death [ISO]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein complex disassembly [ISO]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein localization to cell surface [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein transport [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of synaptic transmission [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of translational initiation by iron [IDA]
- positive regulation of vitamin D biosynthetic process [ISO]
- protein import into nucleus, translocation [ISO]
- protein kinase B signaling [ISO]
- receptor biosynthetic process [ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of branching involved in salivary gland morphogenesis [IDA, IMP]
- regulation of cell proliferation [IDA]
- regulation of immunoglobulin secretion [IDA]
- regulation of insulin secretion [ISO]
- regulation of osteoclast differentiation [IDA]
- regulation of protein phosphorylation [IDA]
- regulation of protein secretion [IDA]
- regulation of reactive oxygen species metabolic process [IDA]
- response to glucocorticoid [ISO]
- response to virus [ISO]
- sequestering of triglyceride [ISO]
- signal transduction [ISO]
- transformed cell apoptotic process [ISO, TAS]
- tumor necrosis factor-mediated signaling pathway [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [ISO]
- external side of plasma membrane [IDA]
- extracellular space [IDA, ISO]
- integral component of membrane [ISO]
- integral component of plasma membrane [ISO, TAS]
- intracellular [IDA, IGI]
- membrane raft [IDA, ISO]
- phagocytic cup [IDA]
- plasma membrane [IDA]
- recycling endosome [IDA]
- secretory granule [TAS]
Download Curated Data for this Protein
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- Interactors 20
- Interactions 33
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