Identification and expression of Ima, a novel Ral-interacting Drosophila protein.
We report the identification of Ima, a novel Drosophila MAGUK-like protein, which contains two WW and four PDZ protein interaction domains and interacts with the small GTPase dRal in the yeast two-hybrid system and pull-down assays. The gene is expressed in distinct spatiotemporal patterns throughout embryonic development. Overexpression of Ima ... interferes with normal Drosophila development, indicating that the gene functions in a tissue specific manner.
Mesh Terms:
Animals, Drosophila, Drosophila Proteins, Molecular Sequence Data, Protein Structure, Tertiary, Two-Hybrid System Techniques, ral GTP-Binding Proteins
Animals, Drosophila, Drosophila Proteins, Molecular Sequence Data, Protein Structure, Tertiary, Two-Hybrid System Techniques, ral GTP-Binding Proteins
Mech. Dev.
Date: Dec. 01, 2002
PubMed ID: 14516694
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