Mediator-nucleosome interaction.
Mediator, a multiprotein complex involved in the regulation of RNA polymerase II transcription, binds to nucleosomes and acetylates histones. Three lines of evidence identify the Nut1 subunit of Mediator as responsible for the histone acetyltransferase (HAT) activity. An "in-gel" HAT assay reveals a single band of the appropriate size. Sequence ... alignment shows significant similarity of Nut1 to the GCN5-related N-acetyltransferase superfamily. Finally, recombinant Nut1 exhibits HAT activity in an in-gel assay.
Mesh Terms:
Acetyltransferases, Amino Acid Sequence, Base Sequence, DNA Primers, Fungal Proteins, Histone Acetyltransferases, Macromolecular Substances, Mediator Complex, Molecular Sequence Data, Multiprotein Complexes, Nuclear Proteins, Nucleosomes, RNA Polymerase II, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid
Acetyltransferases, Amino Acid Sequence, Base Sequence, DNA Primers, Fungal Proteins, Histone Acetyltransferases, Macromolecular Substances, Mediator Complex, Molecular Sequence Data, Multiprotein Complexes, Nuclear Proteins, Nucleosomes, RNA Polymerase II, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid
Mol. Cell
Date: Jul. 01, 2000
PubMed ID: 10949041
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