Sam68 Allows Selective Targeting of Human Cancer Stem Cells.
Targeting of human cancer stem cells (CSCs) requires the identification of vulnerabilities unique to CSCs versus healthy resident stem cells (SCs). Unfortunately, dysregulated pathways that support transformed CSCs, such as Wnt/β-catenin signaling, are also critical regulators of healthy SCs. Using the ICG-001 and CWP family of small molecules, we reveal ... Sam68 as a previously unappreciated modulator of Wnt/β-catenin signaling within CSCs. Disruption of CBP-β-catenin interaction via ICG-001/CWP induces the formation of a Sam68-CBP complex in CSCs that alters Wnt signaling toward apoptosis and differentiation induction. Our study identifies Sam68 as a regulator of human CSC vulnerability.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Adult, Aged, Animals, Apoptosis, Azabicyclo Compounds, Breast Neoplasms, Bridged Bicyclo Compounds, Heterocyclic, Cell Differentiation, Cells, Cultured, Colonic Neoplasms, DNA-Binding Proteins, Female, Humans, Leukemia, Myeloid, Acute, Male, Mice, Mice, Inbred NOD, Middle Aged, Neoplastic Stem Cells, Organophosphates, Peptide Fragments, Proto-Oncogene Proteins c-myc, Pyrimidinones, RNA Interference, RNA-Binding Proteins, Sialoglycoproteins, Sumoylation, Transcriptome, Wnt Signaling Pathway, beta Catenin
Adaptor Proteins, Signal Transducing, Adult, Aged, Animals, Apoptosis, Azabicyclo Compounds, Breast Neoplasms, Bridged Bicyclo Compounds, Heterocyclic, Cell Differentiation, Cells, Cultured, Colonic Neoplasms, DNA-Binding Proteins, Female, Humans, Leukemia, Myeloid, Acute, Male, Mice, Mice, Inbred NOD, Middle Aged, Neoplastic Stem Cells, Organophosphates, Peptide Fragments, Proto-Oncogene Proteins c-myc, Pyrimidinones, RNA Interference, RNA-Binding Proteins, Sialoglycoproteins, Sumoylation, Transcriptome, Wnt Signaling Pathway, beta Catenin
Cell Chem Biol
Date: Jul. 20, 2017
PubMed ID: 28648376
View in: Pubmed Google Scholar
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