Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3.
Human β-defensins 2 and 3 are small cationic peptides with antimicrobial activity against the fungal pathogen Candida albicans. We found that hog1 and pbs2 mutants were hypersensitive to treatment with these peptides, pointing to a role of the high-osmolarity glycerol (HOG) pathway in the response to defensin-induced cell injury.
Mesh Terms:
Antifungal Agents, Antimicrobial Cationic Peptides, Candida albicans, Cell Proliferation, Defensins, Fungal Proteins, High-Throughput Screening Assays, Humans, Mitogen-Activated Protein Kinases, Signal Transduction, beta-Defensins
Antifungal Agents, Antimicrobial Cationic Peptides, Candida albicans, Cell Proliferation, Defensins, Fungal Proteins, High-Throughput Screening Assays, Humans, Mitogen-Activated Protein Kinases, Signal Transduction, beta-Defensins
Eukaryotic Cell
Date: Feb. 01, 2011
PubMed ID: 21131433
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