Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies.

The HIF-1α/p300 protein-protein interaction plays a key role in tumor metabolism and thus represents a high value target for anticancer drug-development. Although several studies have identified inhibitor candidates using rationale design, more detailed understanding of the interaction and binding interface is necessary to inform development of superior inhibitors. In this ...
work, we report a detailed biophysical analysis of the native interaction with both peptide and Adhiron phage display experiments to identify novel binding motifs and binding regions of the surface of p300 to inform future inhibitor design.
Mesh Terms:
Binding Sites, E1A-Associated p300 Protein, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Models, Molecular, Peptide Library, Peptides, Protein Binding, Protein Interaction Maps, Protein Structure, Secondary
Mol Biosyst
Date: Oct. 01, 2015
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