Ibp1p, a novel Cdc25-related phosphatase, suppresses Schizosaccharomyces pombe hsk1 ( cdc7).

We report the identification of a novel Cdc25-like protein phosphatase, Ibp1, in the fission yeast Schizosaccharomyces pombe. Ibp1 is closely related to the catalytic subunit of the Cdc25 dual-specificity phosphatases and has phosphatase activity in vitro. Over-production of catalytically active Ibp1 robustly suppresses a mutation in the replication initiation kinase ...
Hsk1p, a member of the Cdc7 family of protein kinases and weakly suppresses mutation of Rad4/Cut5, a DNA polymerase epsilon-associated factor. Ibp1 is not required for viability, suggesting it may be a non-essential regulator of DNA replication or chromosome structure during S phase.
Mesh Terms:
Amino Acid Sequence, Cell Cycle Proteins, DNA Replication, Gene Expression Regulation, Fungal, Molecular Sequence Data, Protein-Serine-Threonine Kinases, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Sequence Homology, Amino Acid, cdc25 Phosphatases
Curr. Genet.
Date: Oct. 01, 2003
Download Curated Data For This Publication
21077
Switch View:
  • Interactions 4