Mus musculus
SIRT2
5730427M03Rik, SIR2L2, Sir2l
sirtuin 2
GO Process (46)
GO Function (14)
GO Component (23)
Gene Ontology Biological Process
- cellular lipid catabolic process [IMP]
- cellular response to caloric restriction [IDA]
- cellular response to epinephrine stimulus [IDA]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to hypoxia [ISO]
- cellular response to molecule of bacterial origin [ISO]
- cellular response to oxidative stress [IDA]
- hepatocyte growth factor receptor signaling pathway [ISO]
- histone H3 deacetylation [IMP, ISO]
- histone H4 deacetylation [IMP, ISO]
- histone deacetylation [IGI]
- myelination in peripheral nervous system [IMP, ISO]
- negative regulation of NLRP3 inflammasome complex assembly [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of autophagy [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of defense response to bacterium [IMP, ISO]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of oligodendrocyte differentiation [ISO]
- negative regulation of oligodendrocyte progenitor proliferation [ISO]
- negative regulation of peptidyl-threonine phosphorylation [IMP]
- negative regulation of protein catabolic process [ISO]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of striated muscle tissue development [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- peptidyl-lysine deacetylation [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of DNA binding [IDA]
- positive regulation of attachment of spindle microtubules to kinetochore [IMP]
- positive regulation of cell division [IMP]
- positive regulation of execution phase of apoptosis [IMP]
- positive regulation of meiosis [IMP]
- positive regulation of oocyte maturation [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein deacetylation [IDA, IMP, ISO]
- protein kinase B signaling [ISO]
- regulation of cell cycle [ISO]
- regulation of fat cell differentiation [IMP]
- regulation of myelination [IMP, ISO]
- ripoptosome assembly involved in necroptotic process [IMP]
- tubulin deacetylation [IGI, IMP, ISO]
Gene Ontology Molecular Function- NAD+ binding [ISO]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [ISO]
- NAD-dependent protein deacetylase activity [ISO]
- beta-tubulin binding [IDA]
- chromatin binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase activity [IMP, ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP, ISO]
- transcription factor binding [IPI, ISO]
- tubulin deacetylase activity [IMP, ISO]
- ubiquitin binding [ISO]
- zinc ion binding [ISO]
- NAD+ binding [ISO]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [ISO]
- NAD-dependent protein deacetylase activity [ISO]
- beta-tubulin binding [IDA]
- chromatin binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase activity [IMP, ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP, ISO]
- transcription factor binding [IPI, ISO]
- tubulin deacetylase activity [IMP, ISO]
- ubiquitin binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA, ISO]
- centriole [ISO]
- centrosome [ISO]
- chromosome [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- glial cell projection [ISO]
- juxtaparanode region of axon [ISO]
- lateral loop [ISO]
- meiotic spindle [IDA]
- microtubule [ISO]
- midbody [IDA, ISO]
- mitotic spindle [ISO]
- myelin sheath [IDA, ISO]
- myelin sheath abaxonal region [ISO]
- nuclear heterochromatin [ISO]
- nucleus [IDA, ISO]
- paranodal junction [IDA, ISO]
- paranode region of axon [ISO]
- perikaryon [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- spindle [ISO]
- terminal loop [ISO]
Download Curated Data for this Protein
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- Interactors 27
- Interactions 37
- Network
- PTM Sites 33