The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis.

The newly discovered fission yeast mitotic control element nim1+ (new inducer of mitosis) is the first dose-dependent mitotic inducer identified as a protein kinase homolog. Increased nim1+ expression rescues mutants lacking the mitotic inducer cdc25+ and advances cells into mitosis at a reduced cell size; loss of nim1+ delays mitosis ...
until cells have grown to a larger size. The nim1+ gene potentially encodes a 50 kd protein that contains the consensus sequences of protein kinases. Genetic evidence indicates that nim1+ is a negative regulator of the wee1+ mitotic inhibitor, another protein kinase homolog. The combined mitotic induction activities of nim1+ and cdc25+ counteract the wee1+ mitotic inhibitor in a regulatory network that appears also to involve the cdc2+ protein kinase, which is required for mitosis.
Mesh Terms:
Alleles, Amino Acid Sequence, Base Sequence, Genes, Genes, Fungal, Genes, Regulator, Genotype, Mitosis, Mutation, Protein Kinases, Saccharomycetales, Schizosaccharomyces, Sequence Homology, Nucleic Acid
Cell
Date: May. 22, 1987
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