Identification of STS-1 as a novel ShcA-binding protein.
ShcA is a cytoplasmic signaling protein that supports signal transduction by receptor protein-tyrosine kinases by providing auxiliary tyrosine phosphorylation sites that engage additional signaling proteins. The principal binding partner for tyrosine phosphorylation sites on ShcA is Grb2. In the current study, we have used phosphotyrosine-containing peptides to isolate and identify ... STS-1 as a novel ShcA-binding protein. Our results further show that the interaction between STS-1 and ShcA is regulated in response to EGF receptor activation.
Mesh Terms:
A549 Cells, Amino Acid Sequence, Animals, Binding Sites, COS Cells, Cercopithecus aethiops, Epidermal Growth Factor, Gene Expression, Humans, Peptides, Phosphoproteins, Phosphorylation, Phosphotyrosine, Protein Binding, Protein Tyrosine Phosphatases, Sequence Alignment, Signal Transduction, Src Homology 2 Domain-Containing, Transforming Protein 1
A549 Cells, Amino Acid Sequence, Animals, Binding Sites, COS Cells, Cercopithecus aethiops, Epidermal Growth Factor, Gene Expression, Humans, Peptides, Phosphoproteins, Phosphorylation, Phosphotyrosine, Protein Binding, Protein Tyrosine Phosphatases, Sequence Alignment, Signal Transduction, Src Homology 2 Domain-Containing, Transforming Protein 1
Biochem. Biophys. Res. Commun.
Date: Dec. 02, 2016
PubMed ID: 28690151
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