Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway.
Cortactin (CTTN) is overexpressed in various tumors, including head and neck squamous cell carcinoma and colorectal cancer (CRC), and can serve as a biomarker of cancer metastasis. We observed that CTTN promotes cancer cell proliferation in vitro and increases CRC tumor xenograft growth in vivo. CTTN expression increases EGFR protein ... levels and enhances the activation of the MAPK signaling pathway. CTTN expression also inhibits the ubiquitin-mediated degradation of EGFR by suppressing the coupling of c-Cbl with EGFR. CoIP experiments indicate CTTN can interact with c-Cbl in CRC cells. These results demonstrate that CTTN promotes the proliferation of CRC cells and suppresses the degradation of EGFR.
Mesh Terms:
Animals, Cell Line, Tumor, Cell Proliferation, Colorectal Neoplasms, Cortactin, HCT116 Cells, HT29 Cells, Heterografts, Humans, MAP Kinase Signaling System, Male, Mice, Receptor, Epidermal Growth Factor
Animals, Cell Line, Tumor, Cell Proliferation, Colorectal Neoplasms, Cortactin, HCT116 Cells, HT29 Cells, Heterografts, Humans, MAP Kinase Signaling System, Male, Mice, Receptor, Epidermal Growth Factor
Oncotarget
Date: Jan. 03, 2017
PubMed ID: 27903975
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