Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism.

Department of Biochemistry and Molecular Biology, The University of Tokyo, Graduate School of Medicine, Bunkyo-ku, Tokyo 113-0033, Japan.
During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified Cohesin-associated protein Pds5p hinders the establishment of cohesion until counteracted by Eso1p, yet stabilizes cohesion once it is established. Eso1p interacts physically with Pds5p via its Ctf7p/Eco1p-homologous domain.
Mesh Terms:
Acetyltransferases, Cell Cycle Proteins, Chromatids, Chromosomal Proteins, Non-Histone, DNA Replication, DNA, Fungal, Fungal Proteins, G2 Phase, Macromolecular Substances, Nuclear Proteins, Phosphoproteins, S Phase, Saccharomyces cerevisiae Proteins, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Sequence Homology, Amino Acid, Two-Hybrid System Techniques
EMBO J. Oct. 15, 2001; 20(20);5779-90 [PUBMED:11598020]
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