Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression.

Kindlin-2 promotes carcinogenesis through regulation of cell-cell and cell-extracellular matrix adhesion. However, the role of Kindlin-2 in glioma has not been elucidated. We investigated Kindlin-2 expression in 188 human glioma tissue samples. High Kindlin-2 expression was correlated with high pathological grade and a worse prognosis. Kindlin-2 promoted glioma cell motility ...
and proliferation both in vitro and in vivo. Importantly, Kindlin-2 activated the EGFR pathway and increased EGFR mRNA levels. In addition to up-regulating Y-box binding protein-1 (YB-1) and β-catenin expression, Kindlin-2 formed a transcriptional complex with YB-1 and β-catenin that bound to the EGFR promoter and enhanced transcription. The β-catenin/YB-1/EGFR pathway was required for Kindlin-2-mediated functions. Our data provide a better understanding of the mechanisms underlying glioma progression, and suggest that Kindlin-2 may be a biomarker and therapeutic target in glioma.
Mesh Terms:
Adult, Cell Line, Tumor, Cell Movement, Cell Proliferation, Disease Progression, ErbB Receptors, Female, Gene Expression Regulation, Neoplastic, Glioma, Humans, Kaplan-Meier Estimate, Male, Membrane Proteins, Middle Aged, Neoplasm Grading, Neoplasm Proteins, Prognosis, Promoter Regions, Genetic, Protein Binding, Signal Transduction, Transcription, Genetic, Y-Box-Binding Protein 1, Young Adult, beta Catenin
Oncotarget
Date: Nov. 15, 2016
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