Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables.
Yeast Aim21 is recruited by the SH3-containing proteins Bbc1 and Abp1 to patches and, with Tda2, reduces barbed end assembly to balance the distribution of actin between patches and cables. Aim21/Tda2 also interacts with Cap1/Cap2, revealing a complex interplay between actin assembly regulators.
Mesh Terms:
Actin Capping Proteins, Actin Cytoskeleton, Actins, Cytoskeletal Proteins, Endocytosis, Genotype, Microfilament Proteins, Microscopy, Fluorescence, Models, Molecular, Mutation, Protein Binding, Protein Conformation, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Signal Transduction
Actin Capping Proteins, Actin Cytoskeleton, Actins, Cytoskeletal Proteins, Endocytosis, Genotype, Microfilament Proteins, Microscopy, Fluorescence, Models, Molecular, Mutation, Protein Binding, Protein Conformation, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Signal Transduction
Mol. Biol. Cell
Date: Dec. 15, 2017
PubMed ID: 29467252
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