Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.
The shc oncogene product is tyrosine-phosphorylated by Src family kinases and after its phosphorylation interacts with the adapter protein Grb2 (growth factor receptor-bound protein 2). In turn, Grb2 interacts with the guanine nucleotide exchange factor for Ras, mSOS. Because several Src family kinases participate in T cell activation and Shc ... functions upstream of Ras, the role of Shc in T cell signaling was examined. Shc was phosphorylated on tyrosine after activation through the T cell receptor (TCR), and subsequently interacted with Grb2 and mSOS. The Src homology region 2 (SH2) domain of Shc directly interacted with the tyrosine-phosphorylated zeta chain of the TCR. Thus, Shc may couple TCR activation to the Ras signaling pathway.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Cell Line, ErbB Receptors, GRB2 Adaptor Protein, GTP-Binding Proteins, Humans, Hybridomas, Lymphocyte Activation, Membrane Proteins, Molecular Sequence Data, Oncogene Proteins, Phosphorylation, Proteins, Receptors, Antigen, T-Cell, Recombinant Fusion Proteins, Signal Transduction, Son of Sevenless Proteins, T-Lymphocytes, Tyrosine
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Cell Line, ErbB Receptors, GRB2 Adaptor Protein, GTP-Binding Proteins, Humans, Hybridomas, Lymphocyte Activation, Membrane Proteins, Molecular Sequence Data, Oncogene Proteins, Phosphorylation, Proteins, Receptors, Antigen, T-Cell, Recombinant Fusion Proteins, Signal Transduction, Son of Sevenless Proteins, T-Lymphocytes, Tyrosine
Science
Date: Nov. 05, 1993
PubMed ID: 8235613
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