Mus musculus
SIRT1
AA673258, SIR2L1, Sir2, Sir2a, Sir2alpha
sirtuin 1
GO Process (101)
GO Function (21)
GO Component (18)
Gene Ontology Biological Process
- DNA synthesis involved in DNA repair [IMP]
- angiogenesis [ISO]
- behavioral response to starvation [IMP]
- cellular glucose homeostasis [IMP]
- cellular response to DNA damage stimulus [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to hypoxia [ISO]
- cellular response to ionizing radiation [IMP]
- cellular response to starvation [IMP]
- cellular response to tumor necrosis factor [ISO]
- cellular triglyceride homeostasis [IMP]
- cholesterol homeostasis [IMP]
- chromatin organization [ISO]
- chromatin silencing at rDNA [ISO]
- circadian regulation of gene expression [IMP, ISO]
- establishment of chromatin silencing [ISO]
- fatty acid homeostasis [IMP]
- histone H3 deacetylation [IDA, ISO]
- histone H3-K9 modification [IDA]
- histone deacetylation [IDA, IGI, ISA, ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- maintenance of chromatin silencing [ISO]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of TOR signaling [IMP, ISO]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cAMP-dependent protein kinase activity [ISO]
- negative regulation of cardiac muscle cell apoptotic process [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cellular response to testosterone stimulus [ISO]
- negative regulation of cellular senescence [ISO]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fibroblast apoptotic process [ISO]
- negative regulation of growth hormone secretion [ISO]
- negative regulation of helicase activity [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- negative regulation of neuron death [IGI]
- negative regulation of nucleic acid-templated transcription [IMP]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- negative regulation of peptidyl-lysine acetylation [ISO]
- negative regulation of phosphorylation [IMP, ISO]
- negative regulation of prostaglandin biosynthetic process [IMP]
- negative regulation of protein kinase B signaling [IMP, ISO]
- negative regulation of reactive oxygen species biosynthetic process [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- negative regulation of tumor necrosis factor production [ISO]
- ovulation from ovarian follicle [IMP]
- peptidyl-lysine acetylation [ISO]
- peptidyl-lysine deacetylation [ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of MHC class II biosynthetic process [ISO]
- positive regulation of adaptive immune response [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cAMP-dependent protein kinase activity [IDA, ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cellular senescence [ISO]
- positive regulation of cholesterol efflux [IMP]
- positive regulation of chromatin silencing [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of gluconeogenesis [ISO]
- positive regulation of heart rate [ISO]
- positive regulation of histone H3-K9 methylation [ISO]
- positive regulation of insulin receptor signaling pathway [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- positive regulation of macroautophagy [IDA, ISO]
- positive regulation of macrophage apoptotic process [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of skeletal muscle cell proliferation [ISO]
- positive regulation of thyroid-stimulating hormone secretion [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of vasodilation [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein deacetylation [IDA, IMP, ISO]
- protein destabilization [IDA]
- protein ubiquitination [ISO]
- pyrimidine dimer repair by nucleotide-excision repair [IMP, ISO]
- regulation of bile acid biosynthetic process [IMP]
- regulation of cell proliferation [ISO]
- regulation of endodeoxyribonuclease activity [ISO]
- regulation of energy homeostasis [ISO]
- regulation of glucose metabolic process [IMP]
- regulation of mitotic cell cycle [ISO]
- regulation of peroxisome proliferator activated receptor signaling pathway [IMP]
- regulation of protein import into nucleus, translocation [ISO]
- regulation of smooth muscle cell apoptotic process [IDA]
- response to ethanol [ISO]
- response to hydrogen peroxide [ISO]
- response to insulin [IDA]
- response to oxidative stress [ISO]
- single strand break repair [ISO]
- spermatogenesis [IMP]
- triglyceride mobilization [IMP]
- white fat cell differentiation [IMP]
Gene Ontology Molecular Function- HLH domain binding [ISO]
- NAD-dependent histone deacetylase activity [IDA, ISA, ISO]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [IDA]
- NAD-dependent protein deacetylase activity [IDA, ISO]
- bHLH transcription factor binding [ISO]
- core promoter sequence-specific DNA binding [IDA]
- deacetylase activity [IMP, ISO]
- enzyme binding [IPI, ISO]
- histone binding [ISO]
- histone deacetylase activity [ISO]
- identical protein binding [ISO]
- keratin filament binding [ISO]
- mitogen-activated protein kinase binding [ISO]
- p53 binding [IPI, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP, ISO]
- protein domain specific binding [IPI]
- protein kinase B binding [ISO]
- transcription corepressor activity [IMP, ISO]
- transcription factor binding [ISO]
- HLH domain binding [ISO]
- NAD-dependent histone deacetylase activity [IDA, ISA, ISO]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [IDA]
- NAD-dependent protein deacetylase activity [IDA, ISO]
- bHLH transcription factor binding [ISO]
- core promoter sequence-specific DNA binding [IDA]
- deacetylase activity [IMP, ISO]
- enzyme binding [IPI, ISO]
- histone binding [ISO]
- histone deacetylase activity [ISO]
- identical protein binding [ISO]
- keratin filament binding [ISO]
- mitogen-activated protein kinase binding [ISO]
- p53 binding [IPI, ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP, ISO]
- protein domain specific binding [IPI]
- protein kinase B binding [ISO]
- transcription corepressor activity [IMP, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- ESC/E(Z) complex [ISO]
- PML body [ISO]
- axon [ISO]
- cell [IMP]
- chromatin [IDA]
- chromatin silencing complex [ISO]
- cytoplasm [IDA]
- cytosol [ISO]
- growth cone [ISO]
- mitochondrion [ISO]
- nuclear chromatin [ISO]
- nuclear envelope [ISO]
- nuclear euchromatin [ISO]
- nuclear heterochromatin [IDA, ISO]
- nuclear inner membrane [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- rDNA heterochromatin [ISO]
Download Curated Data for this Protein
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- Interactors 53
- Interactions 78
- Network
- PTM Sites 1