The nucleocapsid protein of SARS-associated coronavirus inhibits B23 phosphorylation.

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is responsible for SARS infection. Nucleocapsid (N) protein of SARS-CoV encapsidates the viral RNA and plays an important role in virus particle assembly and release. In this study, the N protein of SARS-CoV was found to associate with B23, a phosphoprotein in nucleolus, in ...
vitro and in vivo. Mapping studies localized the critical N sequences for this interaction to amino acid residues 175-210, which included a serine/arginine (SR)-rich domain. In vitro phosphorylation assay showed that the N protein inhibited the B23 phosphorylation at Thr199.
Mesh Terms:
Binding Sites, HeLa Cells, Humans, Nuclear Proteins, Nucleocapsid Proteins, Phosphorylation, Protein Binding, SARS Virus
Biochem. Biophys. Res. Commun.
Date: May. 02, 2008
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