Mus musculus
PCSK9
AI415265, AI747682, FH3, HCHOLA3, Narc1, PC9, RP23-159J7.1
proprotein convertase subtilisin/kexin type 9
GO Process (21)
GO Function (10)
GO Component (13)
Gene Ontology Biological Process
- cellular response to insulin stimulus [IDA, ISO]
- cellular response to starvation [IDA, ISO]
- cholesterol homeostasis [ISO, ISS]
- cholesterol metabolic process [IDA]
- lipoprotein metabolic process [IDA]
- low-density lipoprotein particle receptor catabolic process [ISO, ISS]
- low-density lipoprotein receptor particle metabolic process [IDA]
- lysosomal transport [ISO]
- negative regulation of low-density lipoprotein particle clearance [ISO]
- negative regulation of receptor recycling [ISO]
- neuron differentiation [IDA, IMP]
- phospholipid metabolic process [IDA]
- positive regulation of neuron apoptotic process [ISO, ISS]
- positive regulation of receptor internalization [ISO]
- protein autoprocessing [ISO, ISS]
- protein processing [ISO]
- proteolysis [IBA, ISS]
- regulation of low-density lipoprotein particle receptor catabolic process [IMP]
- regulation of neuron apoptotic process [IMP]
- regulation of receptor activity [ISO]
- triglyceride metabolic process [IDA]
Gene Ontology Molecular Function- apolipoprotein binding [IDA]
- apolipoprotein receptor binding [ISO]
- low-density lipoprotein particle binding [IDA]
- low-density lipoprotein particle receptor binding [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein self-association [ISO]
- serine-type endopeptidase activity [IBA, ISO, ISS]
- sodium channel inhibitor activity [ISO]
- very-low-density lipoprotein particle binding [IDA]
- very-low-density lipoprotein particle receptor binding [ISO]
- apolipoprotein binding [IDA]
- apolipoprotein receptor binding [ISO]
- low-density lipoprotein particle binding [IDA]
- low-density lipoprotein particle receptor binding [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein self-association [ISO]
- serine-type endopeptidase activity [IBA, ISO, ISS]
- sodium channel inhibitor activity [ISO]
- very-low-density lipoprotein particle binding [IDA]
- very-low-density lipoprotein particle receptor binding [ISO]
Gene Ontology Cellular Component
- ER to Golgi transport vesicle [IDA]
- Golgi apparatus [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- early endosome [ISO]
- endoplasmic reticulum [IDA, ISO]
- extracellular region [IDA]
- extracellular space [IBA, IDA, ISO]
- late endosome [ISO]
- lysosome [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- rough endoplasmic reticulum [ISO]
221380
10090