Kv4.3 Modulates the Distribution of hERG.
This study examines the interaction between hERG and Kv4.3. The functional interaction between hERG and Kv4.3, expressed in a heterologous cell line, was studied using patch clamp techniques, western blot, immunofluorescence, and co-immunoprecipitation. Co-expression of Kv4.3 with hERG increased hERG current density (tail current after a step to +10?mV: 26?±?3 ... versus 56?±?7 pA/pF, p?
Mesh Terms:
Arrhythmias, Cardiac, Cell Membrane, ERG1 Potassium Channel, HEK293 Cells, HSP70 Heat-Shock Proteins, Heart Failure, Humans, Multiprotein Complexes, Shal Potassium Channels
Arrhythmias, Cardiac, Cell Membrane, ERG1 Potassium Channel, HEK293 Cells, HSP70 Heat-Shock Proteins, Heart Failure, Humans, Multiprotein Complexes, Shal Potassium Channels
Sci Rep
Date: Dec. 19, 2016
PubMed ID: 29259226
View in: Pubmed Google Scholar
Download Curated Data For This Publication
221479
Switch View:
- Interactions 11