Warning: This is a preliminary report that has not been peer-reviewed. It should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information.

Malla TN, Pandey S, Poudyal I, Feliz D, Noda M, Phillips G, Stojkovic E, Schmidt M, Zhou J, Lui I, Liu J, Pance K, Consortium QSB, Zhou XX, Leung KK, Wells JA, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR ... Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, BarsiRhyne B, Belyy V, BarileHill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, GarciaSastre A, Ott M, Vignuzzi M, (QBI) Consortium QBICRGSB, Walter P, Manglik A

The SARS coronavirus 2 main protease 3CLpro tailor cuts various essential virus proteins out of long poly-protein translated from the virus RNA. If the 3CLpro is inhibited, the functional virus proteins cannot form and the virus cannot replicate and assemble. Any compound that inhibits the 3CLpro is therefore a potential ...

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drug to end the pandemic. Here we show that the diffraction power of 3CLpro crystals is effectively destroyed by Ebselen. It appears that Ebselen may be a widely available, relatively cost effective way to eliminate the SARS coronavirus 2.

Date: Aug. 10, 2020

Status: Preliminary Report

View Source: doi: 10.1101/2020.08.10.244525

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