Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.
Novel tetrahydroisoquinolines have been developed as potent PPAR ligands. Evaluation of these compounds in PPARgamma responsive models of type 2 diabetes is described.
Mesh Terms:
Animals, Blood Glucose, Humans, Hypoglycemic Agents, Mice, Models, Molecular, PPAR gamma, Peroxisome Proliferator-Activated Receptors, Rosiglitazone, Tetrahydroisoquinolines, Thiazolidinediones
Animals, Blood Glucose, Humans, Hypoglycemic Agents, Mice, Models, Molecular, PPAR gamma, Peroxisome Proliferator-Activated Receptors, Rosiglitazone, Tetrahydroisoquinolines, Thiazolidinediones
Bioorg Med Chem Lett
Date: Dec. 15, 2006
PubMed ID: 17005393
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