Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.
Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPARgamma- and PPARalpha-selective compounds, exhibits potent dual PPARalpha/gamma agonist activity as demonstrated by in vitro binding and dose overlap in the newly introduced EOB mouse model for glucose lowering and lipid/cholesterol homeostasis.
Mesh Terms:
Animals, Blood Glucose, Cholesterol, HDL, Diabetes Mellitus, Diabetes Mellitus, Type 2, Drug Design, Hypoglycemic Agents, Mice, Mice, Inbred Strains, Propionates, Receptors, Cytoplasmic and Nuclear, Transcription Factors, Triglycerides
Animals, Blood Glucose, Cholesterol, HDL, Diabetes Mellitus, Diabetes Mellitus, Type 2, Drug Design, Hypoglycemic Agents, Mice, Mice, Inbred Strains, Propionates, Receptors, Cytoplasmic and Nuclear, Transcription Factors, Triglycerides
J Med Chem
Date: Jun. 21, 2001
PubMed ID: 11405642
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