Cisplatin binds to the MDM2 RING finger domain and inhibits the ubiquitination activity.

Cisplatin can directly bind to the RING finger domain of MDM2, leading to the zinc-release and protein unfolding. Consequently, cisplatin inhibits the MDM2-mediated ubiquitination, which is the molecular basis of p53 activation. This work provides insight into the cisplatin-induced p53-elevation that is involved in cell apoptosis.
Mesh Terms:
Antineoplastic Agents, Cisplatin, Proto-Oncogene Proteins c-mdm2, RING Finger Domains, Ubiquitination
Chem Commun (Camb)
Date: Apr. 28, 2020
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