PTEN? regulates endocytosis and modulates olfactory function.
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) ? is the first identified isoform of the well-known tumor suppressor PTEN. PTEN? has an evolutionarily conserved 173-aa N terminus compared with canonical PTEN. Recently, PTEN? has been shown to play roles in multiple biologic processes including learning and memory, cardiac ... homeostasis, and antiviral immunity. Here, we report that PTEN? maintains mitral cells in olfactory bulb (OB), regulates endocytosis in OB neurons, and controls olfactory behaviors in mice. We show that PTEN? directly dephosphorylates the endocytic protein amphiphysin and promotes its binding to adaptor-related protein complex 2 subunit ?1 (Ap2b1). In addition, we identified mutations in the N terminus of PTEN? in patients with Parkinson disease and Lewy-body dementia, which are neurodegenerative disorders with early olfactory loss. Overexpression of PTEN? mutant H169N in mice OB reduces odor sensitivity. Our data demonstrate a role of PTEN? in olfactory function and provide insight into the mechanism of olfactory dysfunction in neurologic disorders.-Yuan, Y., Zhao, X., Wang, P., Mei, F., Zhou, J., Jin, Y., McNutt, M. A., Yin, Y. PTEN? regulates endocytosis and modulates olfactory function.
Mesh Terms:
Adaptor Protein Complex beta Subunits, Animals, Cell Line, Endocytosis, Female, HEK293 Cells, Humans, Male, Memory, Mice, Mice, Inbred C57BL, Mice, Knockout, Neurons, Odorants, Olfaction Disorders, Olfactory Bulb, PTEN Phosphohydrolase, Protein Isoforms
Adaptor Protein Complex beta Subunits, Animals, Cell Line, Endocytosis, Female, HEK293 Cells, Humans, Male, Memory, Mice, Mice, Inbred C57BL, Mice, Knockout, Neurons, Odorants, Olfaction Disorders, Olfactory Bulb, PTEN Phosphohydrolase, Protein Isoforms
FASEB J
Date: Dec. 01, 2018
PubMed ID: 31291551
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