Binding sites involved in the interaction of actin with the N-terminal region of dystrophin.
Two actin-binding sites have been identified on human dystrophin by proton NMR spectroscopy of synthetic peptides corresponding to defined regions of the polypeptide sequence. These are Actin-Binding Site 1 (ABS1) located at residues 17-26 and Actin-Binding Site 2 (ABS2) in the region of residues 128-156. Using defined fragments of the ... actin amino acid sequence, ABS1 has been shown to bind to actin in the region represented by residues 83-117 and ABS2 to the C-terminal region represented by residues 350-375. These dystrophin-binding sites lie on the exposed domain in the actin filament.
Mesh Terms:
Actins, Amino Acid Sequence, Animals, Binding Sites, Chickens, Dystrophin, Humans, Molecular Sequence Data, Protein Binding, Spectrin, Structure-Activity Relationship
Actins, Amino Acid Sequence, Animals, Binding Sites, Chickens, Dystrophin, Humans, Molecular Sequence Data, Protein Binding, Spectrin, Structure-Activity Relationship
FEBS Lett.
Date: Feb. 17, 1992
PubMed ID: 1544421
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