mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia.
Multiple lines of evidence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia. Integral to PSD glutamatergic signaling is reciprocal interplay between GluN and mGluR5 signaling. We examined agonist-induced mGluR5 signaling in the postmortem dorsolateral prefrontal cortex (DLPFC) derived from 17 patients and age-matched ... and sex-matched controls. The patient group showed a striking reduction in mGluR5 signaling, manifested by decreases in Gq/11 coupling and association with PI3K and Homer compared to controls (p?
Mesh Terms:
Aged, Aged, 80 and over, Antipsychotic Agents, Brain, Excitatory Amino Acid Agents, Female, Humans, Male, Membrane Proteins, Phosphorylation, Post-Synaptic Density, Prefrontal Cortex, Receptor, Metabotropic Glutamate 5, Receptors, N-Methyl-D-Aspartate, Schizophrenia, Signal Transduction
Aged, Aged, 80 and over, Antipsychotic Agents, Brain, Excitatory Amino Acid Agents, Female, Humans, Male, Membrane Proteins, Phosphorylation, Post-Synaptic Density, Prefrontal Cortex, Receptor, Metabotropic Glutamate 5, Receptors, N-Methyl-D-Aspartate, Schizophrenia, Signal Transduction
Mol Psychiatry
Date: Dec. 01, 2019
PubMed ID: 30214040
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