EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.
Eukaryotic translation elongation factor 1? (EEF1D), a subunit of the elongation factor 1 complex of proteins, mediates the elongation process of protein synthesis. Besides this canonical role, EEF1D was found overexpressed in many tumors, like hepatocarcinomas and medulloblastomas. In the present study, we demonstrated for the first time that EEF1D ... may interact with other putative proteins to regulate cell proliferation, migration, and invasion through PI3K/Akt and EMT pathways in glioma. Furthermore, knockdown of EEF1D could reduce cell proliferation and impaired epithelial-mesenchymal transition (EMT) phenotypes, including cell invasion. Taken together, these results indicate that EEF1D and its partner proteins might play a critical role in glioma and serve as a potential therapeutic target of glioma.
Mesh Terms:
Biomarkers, Tumor, Brain Neoplasms, Cell Line, Tumor, Cell Movement, Cell Proliferation, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Glioma, Humans, Neoplasm Grading, Neoplasm Invasiveness, Peptide Elongation Factor 1, Phosphatidylinositol 3-Kinases, Protein Binding, Proto-Oncogene Proteins c-akt, RNA, Messenger, Signal Transduction
Biomarkers, Tumor, Brain Neoplasms, Cell Line, Tumor, Cell Movement, Cell Proliferation, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Glioma, Humans, Neoplasm Grading, Neoplasm Invasiveness, Peptide Elongation Factor 1, Phosphatidylinositol 3-Kinases, Protein Binding, Proto-Oncogene Proteins c-akt, RNA, Messenger, Signal Transduction
Biomed Res Int
Date: Oct. 09, 2020
PubMed ID: 33029523
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