Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions.
We cloned a rHIP1R (GenBank Accession No., AB005052) encoding a Sla2/huntingtin-interacting protein (HIP1) family protein from a rat brain cDNA library. Localization of rHIP1R was investigated in the rat brain using an antibody specific to the HIP1R antibody. The rHIP1R protein was enriched in the synaptic plasma membrane fraction along ... with huntingtin, a synaptic protein and a causal protein for Huntington's disease. The electron microscopic examination revealed that HIP1R was localized at postsynaptic spines. Localization of HIP1R in the small vesicular structures in the spine, possible sites of vesicular transport of synaptic proteins, together with the structure-based analysis, suggested a role of HIP1R for vesicle trafficking through interaction with F-actin and working together with huntingtin and HIP1 at the synaptic sites.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Brain Chemistry, Carrier Proteins, DNA-Binding Proteins, Gene Library, Humans, Male, Mice, Microfilament Proteins, Molecular Sequence Data, RNA, Messenger, Rats, Rats, Wistar, Sequence Homology, Amino Acid, Synapses, Vesicular Transport Proteins
Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Animals, Brain Chemistry, Carrier Proteins, DNA-Binding Proteins, Gene Library, Humans, Male, Mice, Microfilament Proteins, Molecular Sequence Data, RNA, Messenger, Rats, Rats, Wistar, Sequence Homology, Amino Acid, Synapses, Vesicular Transport Proteins
Brain Res
Date: Mar. 28, 2003
PubMed ID: 12650982
View in: Pubmed Google Scholar
Download Curated Data For This Publication
231801
Switch View:
- Interactions 1