Wu S, Zhang Y, You S, Lu S, Zhang N, Sun Y

Septin4, a protein localized at mitochondrion, can promote cells apoptosis mainly by binding XIAP (X-linked inhibitors of apoptosis), however, nothing is known about the role and mechanism of Septin4 in cardiomyocytes apoptosis. Here in the current study, we report that HIF-1? (hypoxia-inducible factor 1 alpha) is a novel interacting protein ...

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with Septin4 at Septin4-GTPase domain. In addition, Septin4 enhances the binding between HIF-1? and the E3 ubiquitin ligase VHL (von Hippel-Lindau protein) to down-regulate HIF-1?, and by reducing cardio-protective factor HIF-1? levels, Septin4 aggravated the hypoxia-induced cardiomyocytes apoptosis. We believe these findings will be beneficial to provide effective strategies for clinical treatment of myocardial ischemia and the subsequent injury caused by myocardial hypoxia.

Date: Jul. 06, 2021

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