The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition.

Name: BIOGRID CURATED DATA FOR PUBLICATION: The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition.
Creator: BioGRID Project

Sacco MD, Hu Y, Gongora MV, Meilleur F, Kemp MT, Zhang X, Wang J, Chen Y

Mesh Terms:
COVID-19, Catalysis, Humans, Mutation, Peptide Hydrolases, SARS-CoV-2

Cell Res

Date: May. 01, 2022

PubMed ID: 35292745

View in: Pubmed Google Scholar

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Publication Summary

The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition.