Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Protein kinases are essential for signal transduction and control of most cellular processes, including metabolism, membrane transport, motility, and cell cycle. Despite the critical role of kinases in cells and their strong association with diseases, good coverage of their interactions is available for only a fraction of the 535 human ...
kinases. Here, we present a comprehensive mass-spectrometry-based analysis of a human kinase interaction network covering more than 300 kinases. The interaction dataset is a high-quality resource with more than 5,000 previously unreported interactions. We extensively characterized the obtained network and were able to identify previously described, as well as predict new, kinase functional associations, including those of the less well-studied kinases PIM3 and protein O-mannose kinase (POMK). Importantly, the presented interaction map is a valuable resource for assisting biomedical studies. We uncover dozens of kinase-disease associations spanning from genetic disorders to complex diseases, including cancer.
Mesh Terms:
Computational Biology, Datasets as Topic, Gene Expression Regulation, Gene Ontology, Gene Regulatory Networks, Genetic Diseases, Inborn, Humans, Metabolic Networks and Pathways, Molecular Sequence Annotation, Muscular Dystrophies, Neoplasms, Neurodegenerative Diseases, Protein Interaction Mapping, Protein Kinases, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins, Signal Transduction
Mol Cell
Date: Dec. 06, 2019
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