SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern.
A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD). Plasma from individuals vaccinated with a Wuhan-1 isolate-based messenger RNA vaccine or from ... convalescent individuals exhibited neutralizing titers that were reduced 2- to 3.5-fold against the B.1.427/B.1.429 variant relative to wild-type pseudoviruses. The L452R mutation reduced neutralizing activity in 14 of 34 RBD-specific monoclonal antibodies (mAbs). The S13I and W152C mutations resulted in total loss of neutralization for 10 of 10 NTD-specific mAbs because the NTD antigenic supersite was remodeled by a shift of the signal peptide cleavage site and the formation of a new disulfide bond, as revealed by mass spectrometry and structural studies.
Mesh Terms:
2019-nCoV Vaccine mRNA-1273, Amino Acid Substitution, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antigens, Viral, BNT162 Vaccine, COVID-19, COVID-19 Vaccines, Cryoelectron Microscopy, Humans, Immune Evasion, Models, Molecular, Mutation, Neutralization Tests, Protein Conformation, Protein Domains, Protein Interaction Domains and Motifs, Protein Subunits, SARS-CoV-2, Spike Glycoprotein, Coronavirus
2019-nCoV Vaccine mRNA-1273, Amino Acid Substitution, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antigens, Viral, BNT162 Vaccine, COVID-19, COVID-19 Vaccines, Cryoelectron Microscopy, Humans, Immune Evasion, Models, Molecular, Mutation, Neutralization Tests, Protein Conformation, Protein Domains, Protein Interaction Domains and Motifs, Protein Subunits, SARS-CoV-2, Spike Glycoprotein, Coronavirus
Science
Date: Aug. 06, 2021
PubMed ID: 34210893
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