Martin-Vicente M, Carrasco I, Munoz-Gomez MJ, Lobo AH, Mas V, Vigil-Vazquez S, Vazquez M, Manzanares A, Cano O, Alonso R, Sepulveda-Crespo D, Tarancon-Diez L, Munoz-Fernandez M A, Munoz-Chapuli M, Resino S, Navarro ML, Martinez I

Pregnant women are vulnerable to severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. Neutralizing antibodies against the SARS-CoV-2 spike (S) protein protect from severe disease. This study analyzes the antibody titers to SARS-CoV-2 S protein in pregnant women and their newborns at delivery, and six months later.We conducted a prospective study on ...

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pregnant women with confirmed SARS-CoV-2 infection and newborns. Antibody (IgG, IgM, and IgA) titers were determined using immunoassays in serum and milk samples. An angiotensin-converting enzyme 2 (ACE2) receptor-binding inhibition assay to the S protein was performed on the same serum and milk samples.At birth, antibodies to SARS-CoV-2 spike protein were detected in 81.9% of mothers' sera, 78.9% of cord blood samples, and 63.2% of milk samples. Symptomatic women had higher antibody titers (IgG, IgM, and IgA) than the asymptomatic ones (P 

Date: Jul. 08, 2022

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