Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding.
Mesh Terms:
Angiotensin-Converting Enzyme 2, Antibodies, Neutralizing, Antibodies, Viral, Antibody Affinity, Gene Expression, Humans, Immune Evasion, Models, Molecular, Mutation, Neutralization Tests, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Receptors, Virus, SARS-CoV-2, Spike Glycoprotein, Coronavirus
Angiotensin-Converting Enzyme 2, Antibodies, Neutralizing, Antibodies, Viral, Antibody Affinity, Gene Expression, Humans, Immune Evasion, Models, Molecular, Mutation, Neutralization Tests, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Receptors, Virus, SARS-CoV-2, Spike Glycoprotein, Coronavirus
Signal Transduct Target Ther
Date: Feb. 21, 2022
PubMed ID: 35190526
View in: Pubmed Google Scholar
Download Curated Data For This Publication
240349
Switch View:
- Interactions 1