Suppression of chromosome instability by targeting a DNA helicase in budding yeast.

Chromosome instability (CIN) is an important driver of cancer initiation, progression, drug resistance, and aging. As such, genes whose inhibition suppresses CIN are potential therapeutic targets. We report here that deletion of an accessory DNA helicase, Rrm3, suppresses high CIN caused by a wide range of genetic or pharmacological perturbations ...
in yeast. Although this helicase mutant has altered cell cycle dynamics, suppression of CIN by rrm3? is independent of the DNA damage and spindle assembly checkpoints. Instead, the rrm3? mutant may have increased kinetochore-microtubule error correction due to an altered localization of Aurora B kinase and associated phosphatase, PP2A-Rts1.
Mesh Terms:
Cell Cycle Proteins, Chromosomal Instability, Chromosome Segregation, DNA Helicases, Kinetochores, M Phase Cell Cycle Checkpoints, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Mol Biol Cell
Date: Jan. 01, 2023
Download Curated Data For This Publication
242089
Switch View:
  • Interactions 23