Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2.
Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV spike protein and show it adopts ... a fully-closed conformation and that, aside from the Receptor-Binding Domain, it resembles the spike of a bat coronavirus RaTG13 more than that of SARS-CoV-2.
Mesh Terms:
Angiotensin-Converting Enzyme 2, Animals, Binding, Competitive, COVID-19, Cryoelectron Microscopy, Evolution, Molecular, Humans, Models, Molecular, Pandemics, Pangolins, Protein Binding, Protein Domains, SARS-CoV-2, Spike Glycoprotein, Coronavirus
Angiotensin-Converting Enzyme 2, Animals, Binding, Competitive, COVID-19, Cryoelectron Microscopy, Evolution, Molecular, Humans, Models, Molecular, Pandemics, Pangolins, Protein Binding, Protein Domains, SARS-CoV-2, Spike Glycoprotein, Coronavirus
Nat Commun
Date: Feb. 05, 2021
PubMed ID: 33547281
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