Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry.

A central question in the study of cell proliferation is, what controls cell-cycle transitions? Although the accumulation of mitotic cyclins drives the transition from the G2 phase to the M phase in embryonic cells, the trigger for mitotic entry in somatic cells remains unknown. We report that the synergistic action ...
of Bora and the kinase Aurora A (Aur-A) controls the G2-M transition. Bora accumulates in the G2 phase and promotes Aur-A-mediated activation of Polo-like kinase 1 (Plk1), leading to the activation of cyclin-dependent kinase 1 and mitotic entry. Mechanistically, Bora interacts with Plk1 and controls the accessibility of its activation loop for phosphorylation and activation by Aur-A. Thus, Bora and Aur-A control mitotic entry, which provides a mechanism for one of the most important yet ill-defined events in the cell cycle.
Mesh Terms:
Animals, Aurora Kinases, CDC2 Protein Kinase, Cell Cycle Proteins, Cell Line, Enzyme Activation, Feedback, Physiological, G2 Phase, HeLa Cells, Humans, Kinetics, Mitosis, Phosphorylation, Protein Binding, Protein Serine-Threonine Kinases, Protein Structure, Tertiary, Proto-Oncogene Proteins, Recombinant Fusion Proteins, Xenopus, Xenopus Proteins
Science
Date: Jun. 20, 2008
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