A universal DNA aptamer as an efficient inhibitor against spike-protein/hACE2 interactions.

A universal aptamer against spike-proteins of diverse SARS-CoV-2 variants was discovered via DNA SELEX towards the wild-type (WT) spike-protein. This aptamer, A1C1, binds to the WT spike-protein or other variants of concern such as Delta and Omicron with low nanomolar affinities. A1C1 inhibited the interaction between hACE2 and various spike-proteins ...
by 85-89%. This universal A1C1 aptamer can be used to design diagnostic and therapeutic molecular tools to target SARS-CoV-2 and its variants.
Mesh Terms:
Angiotensin-Converting Enzyme 2, Aptamers, Nucleotide, COVID-19, Humans, SARS-CoV-2, Spike Glycoprotein, Coronavirus
Chem Commun (Camb)
Date: Jul. 19, 2022
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