Rattus norvegicus
JAK2
Janus kinase 2
GO Process (75)
GO Function (17)
GO Component (8)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- JAK-STAT cascade [IDA, ISO]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISO, ISS]
- STAT protein import into nucleus [ISO]
- activation of JAK2 kinase activity [ISO, ISS]
- activation of MAPKK activity [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO]
- axon regeneration [IMP]
- cell differentiation [ISO]
- cellular response to dexamethasone stimulus [ISO]
- cellular response to lipopolysaccharide [ISO]
- cytokine-mediated signaling pathway [ISO, ISS]
- enzyme linked receptor protein signaling pathway [ISO]
- erythrocyte differentiation [IBA, ISO, ISS]
- extrinsic apoptotic signaling pathway [ISO]
- growth hormone receptor signaling pathway [ISO]
- histone H3-Y41 phosphorylation [IBA, ISO, ISS]
- hormone-mediated signaling pathway [IDA]
- host programmed cell death induced by symbiont [ISO]
- interferon-gamma-mediated signaling pathway [IDA]
- interleukin-12-mediated signaling pathway [ISO]
- intracellular signal transduction [ISO]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- mammary gland epithelium development [ISO]
- mineralocorticoid receptor signaling pathway [IMP]
- myeloid cell differentiation [ISO]
- negative regulation of DNA binding [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cardiac muscle cell apoptotic process [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of cell-cell adhesion [IMP]
- negative regulation of heart contraction [IMP]
- negative regulation of neuron apoptotic process [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet-derived growth factor receptor signaling pathway [IMP]
- positive regulation of DNA binding [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell activation [IMP]
- positive regulation of cell differentiation [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of growth hormone receptor signaling pathway [ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of interleukin-1 beta production [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of phosphoprotein phosphatase activity [IMP]
- positive regulation of protein import into nucleus, translocation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO, ISS]
- positive regulation of tyrosine phosphorylation of Stat5 protein [ISO]
- protein autophosphorylation [IMP, ISO, ISS]
- regulation of inflammatory response [ISO]
- response to antibiotic [ISO]
- response to hydroperoxide [IMP]
- response to interleukin-12 [ISO]
- response to lipopolysaccharide [ISO]
- response to oxidative stress [IMP]
- response to tumor necrosis factor [ISO]
- signal transduction [ISO, ISS]
- tumor necrosis factor-mediated signaling pathway [ISO]
- tyrosine phosphorylation of STAT protein [ISO]
- tyrosine phosphorylation of Stat1 protein [IMP]
- tyrosine phosphorylation of Stat3 protein [IMP]
- tyrosine phosphorylation of Stat5 protein [IMP]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- acetylcholine receptor binding [IPI]
- growth hormone receptor binding [IPI]
- heme binding [ISO, ISS]
- histone binding [ISO, ISS]
- histone kinase activity (H3-Y41 specific) [IBA, ISO, ISS]
- insulin receptor substrate binding [IPI]
- interleukin-12 receptor binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, TAS]
- peptide hormone receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IMP, ISO, ISS]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [IPI]
- SH2 domain binding [ISO]
- acetylcholine receptor binding [IPI]
- growth hormone receptor binding [IPI]
- heme binding [ISO, ISS]
- histone binding [ISO, ISS]
- histone kinase activity (H3-Y41 specific) [IBA, ISO, ISS]
- insulin receptor substrate binding [IPI]
- interleukin-12 receptor binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, TAS]
- peptide hormone receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IMP, ISO, ISS]
- receptor binding [ISO]
- type 1 angiotensin receptor binding [IPI]
Gene Ontology Cellular Component
Download Curated Data for this Protein
246670
10116
Switch View:
- Interactors 9
- Interactions 9
- Network
- PTM Sites 1