MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo.
MORC family CW-type zinc finger 4 (MORC4) possessing nuclear matrix binding domains has been observed to be involved in multiple cancer development. By digging three gene expression omnibus (GEO) gene microarrays (GSE110223, GSE110224 and GSE24514), we found that MORC4 was overexpressed in colorectal cancer (CRC) samples (log2 Fold change >1, ... p?
Mesh Terms:
Cell Line, Tumor, Cell Proliferation, Colorectal Neoplasms, Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinases, Gene Expression Regulation, Neoplastic, Humans, Nuclear Proteins, Polycomb Repressive Complex 1, Transcription Factors, Ubiquitin-Protein Ligases
Cell Line, Tumor, Cell Proliferation, Colorectal Neoplasms, Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinases, Gene Expression Regulation, Neoplastic, Humans, Nuclear Proteins, Polycomb Repressive Complex 1, Transcription Factors, Ubiquitin-Protein Ligases
Cancer Gene Ther
Date: Jul. 01, 2023
PubMed ID: 36932196
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