Rattus norvegicus
SMAD2
Madh2
SMAD family member 2
GO Process (44)
GO Function (20)
GO Component (9)
Gene Ontology Biological Process
- SMAD protein complex assembly [ISO]
- SMAD protein signal transduction [ISO]
- activin receptor signaling pathway [ISO]
- anterior/posterior pattern specification [ISO, ISS]
- cell fate commitment [ISO, ISS]
- common-partner SMAD protein phosphorylation [ISO]
- developmental growth [ISO]
- embryonic cranial skeleton morphogenesis [ISO]
- embryonic foregut morphogenesis [ISO]
- embryonic pattern specification [ISO]
- endoderm development [ISO]
- endoderm formation [ISO]
- gastrulation [ISO]
- heart development [ISO]
- in utero embryonic development [ISO]
- insulin secretion [ISO]
- intracellular signal transduction [ISO, ISS]
- lung development [ISO]
- mesoderm formation [ISO, ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- nodal signaling pathway [ISO]
- organ growth [ISO]
- palate development [ISO]
- pancreas development [ISO]
- paraxial mesoderm morphogenesis [ISO, ISS]
- pattern specification process [ISO]
- pericardium development [ISO]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- post-embryonic development [ISO]
- protein phosphorylation [ISO]
- regulation of binding [ISO, ISS]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- response to cholesterol [ISO]
- response to glucose [ISO]
- signal transduction involved in regulation of gene expression [IMP]
- transforming growth factor beta receptor signaling pathway [IMP, ISO, ISS]
- zygotic specification of dorsal/ventral axis [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- SMAD binding [ISO]
- activating transcription factor binding [ISO]
- chromatin binding [ISO]
- co-SMAD binding [ISO]
- double-stranded DNA binding [ISO, ISS]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI, ISO, ISS]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- SMAD binding [ISO]
- activating transcription factor binding [ISO]
- chromatin binding [ISO]
- co-SMAD binding [ISO]
- double-stranded DNA binding [ISO, ISS]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI, ISO, ISS]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Download Curated Data for this Protein
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- Interactors 3
- Interactions 4
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