TSG101 Physically Interacts with Linear Ubiquitin Chain Assembly Complex (LUBAC) and Upregulates the TNF?-Induced NF-?B Activation.

Linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin E3 ligase complex composed of HOIP, HOIL-1L, and SHARPIN that catalyzes the formation of linear/M1- linked ubiquitin chain. It has been shown to play a pivotal role in the nuclear factor (NF)-?B signaling induced by proinflammatory stimuli. Here, we found that ...
tumor susceptibility gene (TSG101) physically interacts with HOIP, a catalytic component of LUBAC, and potentiates LUBAC activity. Depletion of TSG101 expression by RNA interference decreased TNF?-induced linear ubiquitination and the formation of TNF? receptor 1 signaling complex (TNFRSC). Furthermore, TSG101 facilitated the TNF?-induced stimulation of the NF-?B pathway. Thus, we suggest that TSG101 functions as a positive modulator of HOIP that mediates TNF?-induced NF-?B signaling pathway.
Mesh Terms:
Genes, Regulator, NF-kappa B, Signal Transduction, Tumor Necrosis Factor-alpha, Ubiquitins
Mol Cells
Date: Jul. 31, 2023
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