The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication.
Generation of virus-host protein-protein interactions (PPIs) maps may provide clues to uncover SARS-CoV-2-hijacked cellular processes. However, these PPIs maps were created by expressing each viral protein singularly, which does not reflect the life situation in which certain viral proteins synergistically interact with host proteins. Our results reveal the host-viral protein-protein ... interactome of SARS-CoV-2 NSP3, NSP4, and NSP6 expressed individually or in combination. Furthermore, REEP5/TRAM1 complex interacts with NSP3 at ROs and promotes viral replication. The significance of our research is identifying virus-host interactions that may be targeted for therapeutic intervention.
Mesh Terms:
COVID-19, Coronavirus Papain-Like Proteases, Host Microbial Interactions, Humans, Membrane Glycoproteins, Membrane Proteins, Membrane Transport Proteins, Protein Binding, Protein Interaction Maps, SARS-CoV-2, Viral Nonstructural Proteins, Virus Replication
COVID-19, Coronavirus Papain-Like Proteases, Host Microbial Interactions, Humans, Membrane Glycoproteins, Membrane Proteins, Membrane Transport Proteins, Protein Binding, Protein Interaction Maps, SARS-CoV-2, Viral Nonstructural Proteins, Virus Replication
J Virol
Date: Oct. 31, 2023
PubMed ID: 37768083
View in: Pubmed Google Scholar
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