Caenorhabditis elegans
UNC-17
CELE_ZC416.8a, ZC416.8a
unc-17 encodes a synaptic vesicle acetylcholine transporter (VAChT) highly conserved amongst metazoans including Drosophila and humans (OMIM:600336); UNC-17 is essential for embryonic development, and is required in cholinergic neurons for loading acetylcholine into synaptic vesicles to which UNC-17 is localized; UNC-17 expression may be regulated indirectly by the UNC-4/UNC-37 transcriptional repressor complex, as UNC-17 expression is greatly reduced in unc-4 and unc-37 mutant backgrounds.
GO Process (8)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
- acetylcholine transport [ISS, NAS]
- cation transmembrane transport [IMP, ISS]
- nematode larval development [IMP]
- regulation of locomotion [IMP]
- regulation of muscle contraction [IMP]
- regulation of neurotransmitter secretion [IMP]
- regulation of pharyngeal pumping [IGI, IMP]
- synaptic transmission, cholinergic [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
2550363
6239
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- Interactors 1
- Interactions 1
- Network