E box-dependent activation of telomerase by human papillomavirus type 16 E6 does not require induction of c-myc.
Human papillomavirus type 16 (HPV-16) E6 activates telomerase specifically in epithelial cells. The oncogene c-myc has also been shown to activate telomerase in several cell types. Here we show that while both HPV-16 E6 and c-myc require intact E boxes to transactivate the hTERT promoter, E6 does not induce hTERT ... transcription simply by inducing expression of c-myc. Moreover, hTERT transactivation by HPV-16 E6 correlates with its ability to bind the cellular E6-associated protein (E6AP), suggesting that E6 and E6AP may target a regulator of hTERT expression.
Mesh Terms:
Cells, Cultured, DNA-Binding Proteins, Enzyme Activation, Gene Expression, Humans, Keratinocytes, Oncogene Proteins, Viral, Papillomaviridae, Promoter Regions, Genetic, Proto-Oncogene Proteins c-myc, RNA, Repressor Proteins, Telomerase
Cells, Cultured, DNA-Binding Proteins, Enzyme Activation, Gene Expression, Humans, Keratinocytes, Oncogene Proteins, Viral, Papillomaviridae, Promoter Regions, Genetic, Proto-Oncogene Proteins c-myc, RNA, Repressor Proteins, Telomerase
J Virol
Date: Aug. 01, 2001
PubMed ID: 11435602
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