Rattus norvegicus
TOP2A
topoisomerase (DNA) II alpha
GO Process (24)
GO Function (19)
GO Component (9)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- DNA ligation [ISO]
- DNA topological change [IDA, ISO]
- DNA unwinding involved in DNA replication [IBA]
- aging [IEP]
- apoptotic chromosome condensation [IBA, ISO]
- brain development [IEP]
- cellular response to DNA damage stimulus [ISO]
- cerebellar Purkinje cell differentiation [IEP]
- cerebellar granule cell differentiation [IEP]
- chromosome condensation [ISO]
- chromosome segregation [ISO]
- embryonic cleavage [ISO]
- hematopoietic progenitor cell differentiation [ISO]
- mitotic DNA integrity checkpoint [IBA]
- mitotic recombination [IBA]
- positive regulation of apoptotic process [ISO]
- positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of viral genome replication [ISO]
- resolution of meiotic recombination intermediates [IBA]
- response to drug [IEP]
- response to parathyroid hormone [IEP]
- sister chromatid segregation [IBA]
Gene Ontology Molecular Function- ATP binding [IDA, TAS]
- DNA binding [ISO, TAS]
- DNA binding, bending [ISO, ISS]
- DNA topoisomerase activity [IDA]
- DNA topoisomerase type II (ATP-hydrolyzing) activity [IDA, ISO]
- DNA-dependent ATPase activity [ISO]
- chromatin binding [IDA, ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- magnesium ion binding [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISO]
- sequence-specific DNA binding [IDA]
- structure-specific DNA binding [IDA]
- ubiquitin binding [ISO]
- ATP binding [IDA, TAS]
- DNA binding [ISO, TAS]
- DNA binding, bending [ISO, ISS]
- DNA topoisomerase activity [IDA]
- DNA topoisomerase type II (ATP-hydrolyzing) activity [IDA, ISO]
- DNA-dependent ATPase activity [ISO]
- chromatin binding [IDA, ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- magnesium ion binding [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISO]
- sequence-specific DNA binding [IDA]
- structure-specific DNA binding [IDA]
- ubiquitin binding [ISO]
Gene Ontology Cellular Component
Download Curated Data for this Protein
261906
10116
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- Interactors 4
- Interactions 4
- Network