Identification of a novel mechanism of regulation of Ah (dioxin) receptor function.
Ah receptor (AhR) is a ligand-activated transcription factor that mediates pleiotropic effects of environmental pollutants such as 2,3, 7,8-tetrachlorodibenzo-p-dioxin on host animals. In addition to induction of drug-metabolizing enzymes, the liganded AhR complex was found to activate gene expression of a factor designated AhR repressor (AhRR), which inhibits AhR function ... by competing with AhR for dimerizing with Arnt and binding to the XRE sequence. Thus, AhR and AhRR form a regulatory circuit in the xenobiotic signal transduction pathway and provide a novel mechanism of regulation of AhR function that may determine tissue-specific sensitivity to environmental pollutants.
Mesh Terms:
Amino Acid Sequence, Animals, Aryl Hydrocarbon Receptor Nuclear Translocator, Cloning, Molecular, DNA-Binding Proteins, Dimerization, Gene Expression Regulation, Helix-Loop-Helix Motifs, Mice, Molecular Sequence Data, Promoter Regions, Genetic, Protein Binding, Receptors, Aryl Hydrocarbon, Recombinant Fusion Proteins, Repressor Proteins, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Tetrachlorodibenzodioxin, Transcription Factors, Transcriptional Activation
Amino Acid Sequence, Animals, Aryl Hydrocarbon Receptor Nuclear Translocator, Cloning, Molecular, DNA-Binding Proteins, Dimerization, Gene Expression Regulation, Helix-Loop-Helix Motifs, Mice, Molecular Sequence Data, Promoter Regions, Genetic, Protein Binding, Receptors, Aryl Hydrocarbon, Recombinant Fusion Proteins, Repressor Proteins, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Tetrachlorodibenzodioxin, Transcription Factors, Transcriptional Activation
Genes Dev.
Date: Jan. 01, 1999
PubMed ID: 9887096
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