Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a ... normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.
Mesh Terms:
Cell Division, Cell Line, Cyclin-Dependent Kinase Inhibitor p21, Cyclins, DNA, DNA Damage, DNA Repair, Genes, p53, Humans, Intracellular Signaling Peptides and Proteins, Proliferating Cell Nuclear Antigen, Proteins, Recombinant Proteins, S Phase, Transfection, Tumor Cells, Cultured
Cell Division, Cell Line, Cyclin-Dependent Kinase Inhibitor p21, Cyclins, DNA, DNA Damage, DNA Repair, Genes, p53, Humans, Intracellular Signaling Peptides and Proteins, Proliferating Cell Nuclear Antigen, Proteins, Recombinant Proteins, S Phase, Transfection, Tumor Cells, Cultured
Science
Date: Nov. 25, 1994
PubMed ID: 7973727
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