The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action.
Co-immunoprecipitation experiments in cell extract from cultured cells or target tissues indicated that estrogen receptor was complexed with the retinoblastoma binding protein RIZ in a ligand-dependent manner. Mapping of interaction sites indicated that in both proteins the same regions and motifs responsible for the interaction of transcriptional co-activator and nuclear ... receptors were involved. In cultured cells, estradiol induced a redistribution of RIZ protein within the nucleus and in the cytoplasm. A similar effect was produced in vivo, in prepuberal rat endometrium, by administration of a physiological dose of estradiol. Therefore, RIZ protein could be a specific effector of estrogen action downstream of the hormone-receptor interaction, presumably involved in proliferation control.
Mesh Terms:
Base Sequence, Cell Line, DNA Primers, DNA-Binding Proteins, Estrogens, Humans, Nuclear Proteins, Receptors, Estrogen, Transcription Factors, Zinc Fingers
Base Sequence, Cell Line, DNA Primers, DNA-Binding Proteins, Estrogens, Humans, Nuclear Proteins, Receptors, Estrogen, Transcription Factors, Zinc Fingers
Proc. Natl. Acad. Sci. U.S.A.
Date: Mar. 28, 2000
PubMed ID: 10706618
View in: Pubmed Google Scholar
Download Curated Data For This Publication
3046
Switch View:
- Interactions 2